The museum is housed in the former town hall from the 16th century. It is the first Renaissance building in a bourgeois environment in Northern Bohemia. The museum's collections represent the history of the region from its beginnings to the 20th century. The building is currently being renovated and the exhibition is closed.
The museum also includes the Karel Hynek Mácha Memorial in Litoměřice, which is located in the house Na Vikárce in the World, where the poet Karel Hynek Mácha lived and died on 6 November 1836 (the house is located at Máchova Street 177/5 - a visit must be requested at the ticket office in the administrative building of the Litoměřice Museum or by calling +420 775 868 539).
